After George Sr. escapes from prison to Mexico, Michael swears to leave the family forever. However, he decides to stay and the family gets even more out of control. Buster joins the army and loses a hand. Tobias goes to work for the Blue Man Group. Michael continues to keep his sanity, and his family together at the same time.
George Sr. is at large, making Michael next in line to be prosecuted for the Bluth Company crimes. Meanwhile, Michael is vexed to find that the family is fine without him, and police mistake Oscar for George Sr. and arrest him.
Michael is driven crazy by G.O.B. when he impresses the board as the new company figurehead due to Michael's legal troubles. Meanwhile, George Sr. is arrested in Mexico for a crime Oscar committed, and Buster witnesses something that utterly shocks him.
Michael is increasingly frustrated over being abandoned by the family, and when the staircar is found in Mexico, Michael vows to find his father and give him a piece of his mind. Also, Buster spends time with Lupe's family and thinks he's in Mexico.
Lucille hires Ice, the bounty hunter to find George Sr., who may be closer than everyone thinks. G.O.B. tries to pull off an elaborate illusion, Maeby tries to set Lindsay up with Ice, and Michael tries to mend George Michael's broken relationship.
G.O.B. stages mass firings after being inadvertently roasted at the Bluth Company Christmas party. Plus, Michael is forced to rebuild the Banana Stand, and Buster plays hooky from the Army at an arcade game.
The Bluth's rival development company hires G.O.B., who finds the company president a father figure, in preparation for the Bluth-Sitwell softball game; Lindsay hallucinates from taking anti-depressants.
Michael reunites with his long, lost love Sally Sitwell, but faces interference from parents; meanwhile, the two Lucilles need someone to bid on them at the bachelorette auction with Buster already in a relationship.
With the company in dire financial straits and the Bluths no longer the primary shareholders, Michael must turn to old family friend "Uncle" Jack Dorso for financial assistance. Uncle Jack, however, wants something in return.
Just as Michael's relationship with Sally Sitwell starts to flourish, Maggie Lizer returns nine months pregnant, and Michael immediately assumes he's the father; also, George Michael attempts to break up with Ann, and Buster learns he's being deployed to Iraq.
Lucille abducts George Michael for a mother-son dance; Buster adjusts to having a hook for a hand; G.O.B. reunites with his estranged wife; Tobias stars as George Sr. in a biopic about the Bluth family, which causes Lindsay to become more attracted to him.
George Michael runs for student body president, which G.O.B. manages to ruin; Buster has an affair with Lupe, who is being sought after by Lindsay; Tobias attempts to move out of the model home, then develops a new persona when he regrets his decision.
G.O.B. and Buster team up for some magic illusions to impress Tony Wonder, a rival magician. Meanwhile, Michael is forced to delegate some work when he's hospitalized and Lindsay teaches George Michael how to drive using the staircar.
George Sr. tries to find a way to attend an anniversary dinner for Lucille; Michael deliberatly offends Ann's devout Christian parents; Tobias goes overboard performing his "Mrs. Featherbottom" persona.
G.O.B. hides George Sr. while the model home's plumbing is checked; George Michael helps Ann protest Maeby's new movie; Tobias takes a liking to Kitty after Michael asks him to keep an eye on her.
In 2005, the second season brought eleven Emmy nominations in seven categories and one win, for "Outstanding Writing for a Comedy Series" for the season finale "Righteous Brothers," written by Mitchell Hurwitz and Jim Vallely.
The 2005 Golden Globe Award for "Best Performance by an Actor in a Television Series - Musical or Comedy" for Jason Bateman.